BackgroundSecondary adaptation to aquatic life occurred independently in several amniote lineages, including reptiles during the Mesozoic and mammals during the Cenozoic.These evolutionary shifts to aquatic environments imply major morphological VINE modifications, especially of the feeding apparatus.Mesozoic (250-65 Myr) marine reptiles, such as i
Current understanding on pathogenesis and effective treatment of glycogen storage disease type Ib with empagliflozin: new insights coming from diabetes for its potential implications in other metabolic disorders
Glycogen storage type Ib (GSDIb) is a rare inborn error of metabolism caused by glucose-6-phosphate transporter (G6PT, SLC37A4) deficiency.G6PT defect results in excessive accumulation of glycogen and fat in the liver, kidney, and intestinal mucosa and into both glycogenolysis and gluconeogenesis impairment.Clinical features include hepatomegaly, h
Quality of life of patients with 3D-printed arm prostheses in a rural area of Sierra Leone
Introduction: In Sierra Leone, access to prostheses is limited due to absence of practical knowledge, materials, trained staff, and high cost.This paper investigates the impact of a 3D printed prosthesis on the health-related quality of life (HRQoL) in prosthesis recipients.Methods: Patients with upper extremity amputations were included in this ca
Computational studies on searching potential phytochemicals against DNA polymerase activity of the monkeypox virus
Objectives: The outbreak of monkeypox virus (MPXV) is an emerging epidemic of medical concern with 65353 confirmed cases of infection and a fatality of 115 worldwide.Since May 2022, MPXV has been rapidly disseminating across the globe through various Project Patterns modes of transmission, including direct contact, respiratory droplets, and consens